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Most DHEA is sulfated before being released into the bloodstream and circulates as DHEA-sulfate (DHEA-S)

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Recent studies demonstrated that in chronic progressive SCZ, microglial reactivity and immune-oxidative pathway are elevated in early stages associated with age, accompanied by mitochondrial loss and cellular degeneration, whereas continuous schizophrenia shows consistently low microglial reactivity (Rajasekaran et al., 2015